After World War I, much of Greece was left in a deep depression. Thousands of Greeks left their homeland in hope of providing a better life for themselves and their familes in America.  Many settled in New York or Boston, but a small group found their way to Portland. They were welcomed with open arms, and the word of the city's hospitality quickly spread back home throughout the towns and villages.

By 1925, the Greek community in greater Portland had grown to the point where the State of Maine officially recognized the Greek Parishes of Portland and Westbrook. Shortly thereafter, the Parish community bought the old Presbyterian Church on the corner of Pleasant and Park Street.

The church, which was actually built by the Methodists in 1828, is the second-oldest exsisting church in Portland.  Its steeple housed one of only thirteen Liberty Bells cast by the Paul Revere Foundry. The hand-crafted stained glass windows and beautiful, Byzantine Orthodox icons are a sight to behold.

Today the Holy Trinity Greek Orthodox Church of Portland provides a place of worship for over 250 families in the greater Portland area and strives to enhance the spiritual life of its members. Fr. Constantine Sarantides has been Pastor of Holy Trinity for the past 8 years. Jurisdictionally, Holy Trinity belongs to the Greek Orthodox Archdiocese of North & South America. Ecumenical Patriarch Bartholomew of Constantinople (Istanbul) is head of the world wide Orthodox Church.